Measurement of state-dependent action of sodium channel inhibitors
نویسندگان
چکیده
منابع مشابه
State dependent dissociation of HERG channel inhibitors.
BACKGROUND AND PURPOSE Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death. Many drugs induce greater inhibition of HERG channels when the cell membrane is depolarized frequently. The dependence of inhibition on the pulsing rate may yield different IC(50) values at different frequencie...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2009
ISSN: 1662-5137
DOI: 10.3389/conf.neuro.01.2009.04.062